Kinase-activity-independent functions of atypical protein kinase C in Drosophila
نویسندگان
چکیده
منابع مشابه
Kinase-activity-independent functions of atypical protein kinase C in Drosophila.
Polarity of many cell types is controlled by a protein complex consisting of Bazooka/PAR-3 (Baz), PAR-6 and atypical protein kinase C (aPKC). In Drosophila, the Baz-PAR-6-aPKC complex is required for the control of cell polarity in the follicular epithelium, in ectodermal epithelia and neuroblasts. aPKC is the main signaling component of this complex that functions by phosphorylating downstream...
متن کاملTargeted deletion of protein kinase C lambda reveals a distribution of functions between the two atypical protein kinase C isoforms.
Protein kinase C lambda (PKClambda) is an atypical member of the PKC family of serine/threonine kinases with high similarity to the other atypical family member, PKCzeta. This similarity has made it difficult to determine specific roles for the individual atypical isoforms. Both PKClambda and PKCzeta have been implicated in the signal transduction, initiated by mediators of innate immunity, tha...
متن کاملTargeted Deletion of Protein Kinase C Reveals a Distribution of Functions between the Two Atypical Protein Kinase C Isoforms
Protein kinase C (PKC ) is an atypical member of the PKC family of serine/threonine kinases with high similarity to the other atypical family member, PKC . This similarity has made it difficult to determine specific roles for the individual atypical isoforms. Both PKC and PKC have been implicated in the signal transduction, initiated by mediators of innate immunity, that culminates in the activ...
متن کاملBazooka and atypical protein kinase C are required to regulate oocyte differentiation in the Drosophila ovary.
The par genes, identified by their role in the establishment of anterior-posterior polarity in the Caenorhabditis elegans zygote, subsequently have been shown to regulate cellular polarity in diverse cell types by means of an evolutionarily conserved protein complex including PAR-3, PAR-6, and atypical protein kinase C (aPKC). The Drosophila homologs of par-1, par-3 (bazooka, baz), par-6 (DmPar...
متن کاملA rho-binding protein kinase C-like activity is required for the function of protein kinase N in Drosophila development.
The Rho GTPases interact with multiple downstream effectors to exert their biological functions, which include important roles in tissue morphogenesis during the development of multicellular organisms. Among the Rho effectors are the protein kinase N (PKN) proteins, which are protein kinase C (PKC)-like kinases that bind activated Rho GTPases. The PKN proteins are well conserved evolutionarily,...
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ژورنال
عنوان ژورنال: Journal of Cell Science
سال: 2009
ISSN: 1477-9137,0021-9533
DOI: 10.1242/jcs.052514